Alnylam Pharmaceuticals, Inc. (ALNY): price, analyst ratings, earnings and fundamentals
Updated 16 September 2026, 08:02 ET
Alnylam Pharmaceuticals, Inc. (ALNY) closed at $238.27 on 15 September 2026, down 4.7%. The stock is up 4.2% over one month and down 48.9% over one year. It trades 51.9% below its 52-week high of $495.55. Analysts recorded 23 actions in the last 90 days; the median price target of $350 is 46.9% above the last close. The company last reported on 30 July 2026 for Q2 2026: EPS of $1.84 against an estimate of $2.00, a miss of 8.0%, on revenue of $1.3 billion.
Price and performance
Performance figures use dividend and split adjusted closes over trading sessions, so a one-year move compares the last close with the close 252 sessions earlier. The 52-week range uses the adjusted daily highs and lows of the same window. Read the guide: Momentum, trend and technical indicators.
The live chart with technical indicators is in the app: open ALNY in FundSpec.
Analyst ratings
Over the last 90 days FundSpec recorded 23 analyst actions on ALNY from 16 firms: 21 maintained or reiterated a view, 1 upgrade and 1 initiation. Price targets were 3 raised and 16 lowered. The most recent targets from 16 firms range from $256 to $455, with a median of $350, 46.9% above the last close.
| Date | Firm | Action | Price target |
|---|---|---|---|
| 8 Sep 2026 | Jefferies | Maintains Hold | $230.00 to $260.00 |
| 2 Sep 2026 | HC Wainwright & Co. | Reiterates Buy | $455.00 |
| 19 Aug 2026 | BMO Capital | Initiates Coverage On Outperform | $318.00 |
| 14 Aug 2026 | Wells Fargo | Maintains Equal-Weight | $316.00 to $256.00 |
| 4 Aug 2026 | Truist Securities | Maintains Buy | $410.00 to $315.00 |
| 4 Aug 2026 | HC Wainwright & Co. | Maintains Buy | $485.00 to $455.00 |
| 3 Aug 2026 | Raymond James | Upgrades to Strong Buy from Outperform | $420.00 |
| 3 Aug 2026 | Citigroup | Maintains Buy | $380.00 to $340.00 |
| 3 Aug 2026 | Barclays | Maintains Overweight | $527.00 to $450.00 |
| 31 Jul 2026 | JP Morgan | Maintains Overweight | $400.00 to $375.00 |
A price target is one firm's twelve-month view, and the median across firms is a steadier reading than any single call. Upgrades and downgrades matter more when they change a rating, not only a target. Read the guide: What analyst ratings and price targets actually tell you.
Every action with the firm's history is in Analyst Ratings.
Earnings
The next report is scheduled for 29 October 2026 before the open for Q3 2026, with EPS expected at $2.19 on revenue of $1.4 billion. Alnylam Pharmaceuticals, Inc. beat the EPS estimate in 7 of its last 8 reported quarters.
| Period | Reported | EPS estimate | EPS actual | Surprise | Revenue |
|---|---|---|---|---|---|
| Q2 2026 | 30 Jul 2026 | $2.00 | $1.84 | -8.00% | $1.3B |
| Q1 2026 | 30 Apr 2026 | $1.36 | $1.99 | +46.32% | $1.2B |
| Q4 2025 | 12 Feb 2026 | $1.20 | $1.25 | +4.17% | $1.1B |
| Q3 2025 | 30 Oct 2025 | $1.23 | $2.90 | +135.77% | $1.2B |
| Q2 2025 | 31 Jul 2025 | -$0.16 | $0.32 | +300.00% | $773.7M |
| Q1 2025 | 1 May 2025 | -$1.03 | -$0.01 | +99.03% | $594.2M |
| Q4 2024 | 13 Feb 2025 | -$0.14 | $0.06 | +142.86% | $593.2M |
| Q3 2024 | 31 Oct 2024 | -$0.93 | -$0.50 | +46.24% | $500.9M |
An earnings surprise is the reported EPS against the consensus estimate on the day. The price reaction depends as much on guidance and on what was already priced in as on the surprise itself. Read the guide: Earnings season: estimates, surprises and price reaction.
Estimates, confirmed dates and alerts for every company are in Earnings.
Fundamentals
For the period ended 30 June 2026, Alnylam Pharmaceuticals, Inc. reported revenue of $1.3 billion and net income of $164.5 million. On a trailing twelve month basis the company shows revenue growth of 95.14%, a gross margin of 79.79%, an operating margin of 20.81% and a return on equity of 81.14%.
Income statement
| Line | Amount |
|---|---|
| Revenue | $1,290,948,000 |
| Cost of Revenue | $298,261,000 |
| Gross Profit | $992,687,000 |
| Research and Development | $413,134,000 |
| Selling, General & Administrative Expenses | $347,922,000 |
| Total Operating Expenses | $1,059,507,000 |
| Operating Profit | $231,441,000 |
| Interest Expense | $82,051,000 |
| Pre-tax Income | $177,806,000 |
| Income Tax Expense | $13,312,000 |
| Net Income | $164,494,000 |
Cash flow
| Line | Amount |
|---|---|
| Stock-based Compensation | $86,625,000 |
Assets
| Line | Amount |
|---|---|
| Cash & Cash Equivalents | $1,708,318,000 |
| Restricted Cash | $1,557,000 |
| Accounts & Notes Receivable, Net | $912,739,000 |
| Prepaid Expenses | $302,176,000 |
| Inventory | $97,110,000 |
| Total Current Assets | $4,620,172,000 |
| Plant, Property & Equipment, Net | $554,143,000 |
| Operating Lease Right-of-Use Assets | $183,359,000 |
| Other Long-term Assets | $65,132,000 |
| Total Assets | $5,558,769,000 |
Liabilities and equity
| Line | Amount |
|---|---|
| Accounts Payable & Accrued Expenses | $108,016,000 |
| Operating Lease Liabilities, Current | $45,933,000 |
| Deferred Liability Charges | $4,014,000 |
| Total Current Liabilities | $1,512,513,000 |
| Operating Lease Liabilities, Long-term | $210,495,000 |
| Other Liabilities | $9,152,000 |
| Total Liabilities | $4,204,651,000 |
| Common Stock | $1,337,000 |
| Retained Earnings | -$6,332,039,000 |
| Other Accumulated Comprehensive Income | -$32,138,000 |
| Total Stockholders Equity | $1,354,118,000 |
| Total Liability & Stockholders Equity | $5,558,769,000 |
Figures as filed with the SEC for the period ended 30 June 2026, in US dollars.
FundSpec fundamental metrics
Each metric is computed from the company's filings and ranked against every company FundSpec covers; the percentile is the share of covered companies with a lower value.
Liquidity
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| Cash Ratio | 1.13 | 75th | Calculated as the ratio of Cash and cash equivalents / Current liabilities. This metric calculates the company's ability to repay its short-term debt |
| Current Ratio | 3.05 | 79th | Calculated as the ratio of Current Assets / Current Liabilities. The higher the current ratio, the more capable the company is of paying its obligations |
| Quick Ratio | 1.73 | 76th | Calculated as the ratio of (Cash + Marketable Securities + Accounts Receivable) / Current Liabilities. The quick ratio is a measure of how well a company can meet its short-term financial liabilities. |
Leverage
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| Debt/Assets | 0.00 | 17th | Calculated as the ratio of Short-Term Debt + Long-Term Debt / Total Assets. The higher the ratio, the higher the degree of leverage, and consequently, financial risk |
| Debt/Equity | 0.00 | 14th | Calculated as the ratio of Total Liabilities / Shareholders' Equity. The ratio indicates how much debt a company is using to finance its assets relative to the amount of value represented in shareholders’ equity |
| Degree of Financial Leverage | 1.40 | 81st | Calculated as the ratio of Percentage change in EPS / Percentage change in EBIT. A higher degree of financial leverage means that the company has more volatile EPS. |
Profitability
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| Free Cashflow Margin Pct | 17.1% | 78th | Calculated as the ratio of Free Cashflow from Operating Activities / Net Sales. It measures how much per dollar of revenue the company is able to convert into free cash flow. |
| Gross Margin Pct | 79.8% | 90th | Calculated as the ratio of Revenue - Cost of Goods Sold (COGS) / Revenue. The gross margin represents the percent of total sales revenue that the company retains after incurring the direct costs associated with producing the goods and services sold by a company. |
| Operating Margin Pct | 20.8% | 81st | Calculated as the ratio of (Revenue - (Cost of Goods Sold + Labour + Sales, General & Administrative)) / Revenue. Operating margins are important because they measure efficiency. The higher the operating margin, the more profitable a company's core business is. |
| PreTax Margin Pct | 16.0% | 73rd | Calculated as the ratio of (Gross profit - (Operating Expense + Interest Expense)) / Revenue. The pretax profit margin enables profitability to be compared across companies with significant differences in size, scale, capital structure and tax rates. |
| Return on Assets Pct | 15.3% | 94th | Calculated as the ratio of Net Income / Total Assets. It is an indicator of how efficient the company is at using its assets to generate earnings. |
| Return on Equity Pct | 81.1% | 97th | Calculated as the ratio of Net Income / Shareholders' equity. It is a measure of how much profit a company generates with the money shareholders have invested. |
| Return on Invested Capital Pct | 104.7% | 100th | Calculated as the ratio of (Net Income - Dividends) / (Debt + Equity). It is a measure of how efficient the company is at allocating the capital under its control to profitable investments. |
Cashflow
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| FCF Return on Assets Pct | 16.2% | 94th | Calculated as the ratio of Cashflow from Operations / Total Assets. A high cash return on assets means a company is generating more cash flow from every asset dollar |
Top Line Growth
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| Revenue Pct Growth | 95.1% | 93rd | The Revenue (Sales) growth rate over the trailing twelve months (TTM) |
| Revenue Pct Growth 3 year CAGR | 57.2% | 94th | The Revenue (Sales) compound annual growth rate (CAGR) over the past 3 years |
| Revenue Pct Growth 5 year CAGR | 47.5% | 94th | The Revenue (Sales) compound annual growth rate (CAGR) over the past 5 years |
Taxes
| Metric | Value | Percentile | What it measures |
|---|---|---|---|
| Effective Tax Rate Pct | -1.1% | 17th | The effective tax rate of the company over the trailing twelve months (TTM). |
Margins and returns say how much of each dollar of sales becomes profit and how hard the balance sheet is working; leverage and liquidity say how much room the company has when conditions turn. Read the guide: A practical guide to discounted cash flow valuation.
Fair value, peer multiples and the full statement history are in the app: open ALNY in FundSpec.
Insider activity
No insider transaction was filed in the last 90 days; the most recent is from 1 June 2026.
| Date | Insider | Title | Type | Shares | Price | Value |
|---|---|---|---|---|---|---|
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 1,222 | $299.87 | $366K |
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 1,175 | $298.91 | $351K |
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 921 | $297.71 | $274K |
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 495 | $300.72 | $149K |
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 17 | $302.65 | $5K |
| 1 Jun 2026 | David E I Pyott | Director | Acquisition | 3,830 | ||
| 1 Jun 2026 | David E I Pyott | Director | Disposal | 3,830 | ||
| 1 Jun 2026 | Benjamin Cravatt | Director | Acquisition | 4,393 | ||
| 20 May 2026 | Margaret A Hamburg | Director | Acquisition | 671 | ||
| 20 May 2026 | Peter N Kellogg | Director | Acquisition | 1,441 | ||
| 20 May 2026 | Peter N Kellogg | Director | Acquisition | 671 | ||
| 20 May 2026 | David E I Pyott | Director | Acquisition | 1,441 | ||
| 20 May 2026 | David E I Pyott | Director | Acquisition | 671 | ||
| 20 May 2026 | Colleen F Reitan | Director | Acquisition | 1,441 | ||
| 20 May 2026 | Colleen F Reitan | Director | Acquisition | 671 |
Insider filings record what officers and directors did with their own shares. Disposals are often planned sales or tax related, so a pattern across several insiders says more than one filing.
SEC filings
The latest filing is a 10-Q from 30 July 2026.
| Filed | Form | Document |
|---|---|---|
| 30 Jul 2026 | 10-Q | View on sec.gov |
| 30 Apr 2026 | 10-Q | View on sec.gov |
| 12 Feb 2026 | 10-K | View on sec.gov |
| 30 Oct 2025 | 10-Q | View on sec.gov |
| 31 Jul 2025 | 10-Q | View on sec.gov |
| 1 May 2025 | 10-Q | View on sec.gov |
| 13 Feb 2025 | 10-K | View on sec.gov |
| 31 Oct 2024 | 10-Q | View on sec.gov |
| 1 Aug 2024 | 10-Q | View on sec.gov |
| 2 May 2024 | 10-Q | View on sec.gov |
Company profile
- Exchange
- Nasdaq
- Sector
- Pharmaceuticals, Biotech and Chemicals
- Industry
- Pharmaceutical Products
- Headquarters
- CAMBRIDGE, Massachusetts
- Chief executive
- Yvonne L. Greenstreet
- Employees
- 2,000
- Website
- alnylam.com
- SEC CIK
- 0001178670
Alnylam Pharmaceuticals, Inc. focuses on discovering, developing, and commercializing novel therapeutics based on ribonucleic acid interference. The company's pipeline of investigational RNAi therapeutics focuses on genetic medicines, cardio-metabolic diseases, hepatic infectious diseases, and central nervous system (CNS/ocular) diseases. Its marketed products include ONPATTRO (patisiran), a lipid complex injection for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults.
Sector and peers
Alnylam Pharmaceuticals, Inc. is part of the Pharmaceuticals, Biotech and Chemicals sector, which FundSpec tracks across 614 companies.
Companies in the same industry by market capitalization:
LLY ELI LILLY & CoJNJ Johnson & JohnsonABBV AbbVie Inc.MRK Merck & Co., Inc.NVS Novartis AGAZN Astrazeneca plcABT Abbott LaboratoriesPFE Pfizer Inc.
Put two of them side by side in Compare.
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